Abstract
Aryl sulfonamido tetralins based on lead compound 2a were synthesized and evaluated for Kv1.5 inhibitory activity. Several compounds having IC(50) values less then 0.1 microM were identified. Kv1.5 inhibitors have the potential to be atrium-selective agents for the treatment of atrial fibrillation.
MeSH terms
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Anti-Arrhythmia Agents / chemical synthesis*
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Anti-Arrhythmia Agents / chemistry
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Anti-Arrhythmia Agents / pharmacology
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Humans
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Kv1.5 Potassium Channel / antagonists & inhibitors*
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Kv1.5 Potassium Channel / metabolism
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Potassium Channel Blockers / chemical synthesis*
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Potassium Channel Blockers / chemistry
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Potassium Channel Blockers / pharmacology
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Sulfonamides / chemical synthesis*
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Sulfonamides / chemistry
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Sulfonamides / pharmacology
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Tetrahydronaphthalenes / chemical synthesis*
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Tetrahydronaphthalenes / chemistry
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Tetrahydronaphthalenes / pharmacology
Substances
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Anti-Arrhythmia Agents
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Kv1.5 Potassium Channel
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Potassium Channel Blockers
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Sulfonamides
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Tetrahydronaphthalenes